基本信息

    姓名:
    包永明
    职称:
    教授 博士生导师 硕士生导师
    性别:
    毕业院校:
    大连理工大学
    学位:
    博士
    在职信息:
    在职
    所在单位:
    生物工程学院
    学科:
    生物技术工程
    办公地点:
    大连理工大学生物工程学院323
    电子邮箱:
    biosci@dlut.edu.cn
团队简介

生物催化转化:围绕精细化学品生物制造的科学问题及关键技术,开展酶结构与功能、代谢工程及过程工程研究。包括(1)蛋白质及酶工程;(2)酶制剂开发及应用;(3)代谢工程及代谢控制发酵。重点开展蛋白酶、脂肪酶、氧化还原酶的酶工程及应用,丁二酮、苹果酸等精细化学品的微生物发酵研究。

天然药物药物化学与药理学:围绕药物化学与药理学及新药发现等科学问题及关键技术,开展药物药理、药效、协同作用以及应用的研究。包括(1)神经退行性疾病药物研究;(2)抗肿瘤药物协同作用;(3)继发性骨质疏松保健及治疗(4)酒精依赖及酒精中毒的预防及治疗。

近几年获国家发明专利4项,发表SCI收录50余篇。



代表性成果

  1. Jianli Guo, Qin Tang, Qingling Wang, Wenhui Sun, Zhongji Pu, Jingyun Wang, Yongming Bao. Pifithrin-αenhancing anticancer effect of topotecan on p53- expressing cancer cells.European Journal of Pharmaceutical Sciences 2019, 128: 61–72.

  2. Bo Jiang, Shangli Zheng, Lijia An. Changes in striatal dopamine transporter and tyrosine hydroxylase expression associated with fatigue and their reversal by blueberry juice Journal of Berry Research 2019, 99:1-12.

  3. Zhongji Pu, Mengdi Zhao,Yue Zhang,Wenhui Sun, Yongming Bao. Dynamic Description of the Catalytic Cycle of Malate Enzyme: Stereoselective Recognition of Substrate, Chemical Reaction, and Ligand Release. J. Phys. Chem. B 2018, 122, 12241?12250.

  4. Qingling Wang, Fangling Ji, Jianli Guo, Yuepeng Wang, Yanyan Li, Jingyun Wang, Lijia An, Yongming Bao. LotS/LotR/Clp, a novel signal pathway responding to temperature, modulating protease expression via c-di-GMP mediated manner in Stenotrophomonas maltophilia FF11.Microbiological Research 2018, 214: 60–73.

  5. Meiling Gao, Siyu Yao, Yang Liu, Haining Yu, Pinsan Xu, Wenhui Sun, Zhongji Pu, Hongman Hou, Yongming Bao. Transcriptome Analysis of Tomato Leaf Spot Pathogen Fusarium proliferatum: De novo Assembly, Expression Profiling, and Identification of Candidate Effectors.Int. J. Mol. Sci. 2018, 19(31),doi:10.33-39

  6. Yue Zhang, Fangling Ji, Jingyun Wang, Zhongji Pu, Bo Jiang, Yongming Bao. Purification and characterization of a novel organic solvent tolerant and cold adapted lipase fromPsychrobactersp. ZY124. Extremophiles 2018, 22: 287–300.

  7. Wenbo Hao, Fangling Ji, Jingyun Wang, Yuepeng Wang, Yue Zhang, Yongming Bao. Metabolic engineering of Bacillus sp. for diacetyl production.Process Biochemistry2017, 58: 69–77.

  8. Qin Tang, Fangling Ji, Jingyun Wang, Lianying Guo, Yachen Li, Yongming Bao.Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. European Journal of Pharmaceutical Sciences 2017, 109: 223-232.

  9. Zhongji Pu, Fangling Ji, Jingyun Wang, Yue Zhang, Wenhui Sun,Yongming Bao. Rational design of Meso-2, 3-butanediol dehydrogenase by molecular dynamics simulation and experimental evaluations. FEBS Letter 2017,591: 3402-3413.

  10. Bo. Jiang , R.F. Shen, J. Bia, X.S. Tianb, T Hinchliffeb Y. Xia. Catalpol: A Potential Therapeutic for Neurodegenerative Diseases Current Medicinal Chemistry,1278-1291

代表性成果



专利情况

国家发明专利



论文情况

  1. Jianli Guo, Qin Tang, Qingling Wang, Wenhui Sun, Zhongji Pu, Jingyun Wang, Yongming Bao. Pifithrin-αenhancing anticancer effect of topotecan on p53- expressing cancer cells.European Journal of Pharmaceutical Sciences 2019, 128: 61–72.

  2. Bo Jiang, Shangli Zheng, Lijia An. Changes in striatal dopamine transporter and tyrosine hydroxylase expression associated with fatigue and their reversal by blueberry juice Journal of Berry Research 2019, 99:1-12.

  3. Zhongji Pu, Mengdi Zhao,Yue Zhang,Wenhui Sun, Yongming Bao. Dynamic Description of the Catalytic Cycle of Malate Enzyme: Stereoselective Recognition of Substrate, Chemical Reaction, and Ligand Release. J. Phys. Chem. B 2018, 122, 12241?12250.

  4. Qingling Wang, Fangling Ji, Jianli Guo, Yuepeng Wang, Yanyan Li, Jingyun Wang, Lijia An, Yongming Bao. LotS/LotR/Clp, a novel signal pathway responding to temperature, modulating protease expression via c-di-GMP mediated manner in Stenotrophomonas maltophilia FF11.Microbiological Research 2018, 214: 60–73.

  5. Meiling Gao, Siyu Yao, Yang Liu, Haining Yu, Pinsan Xu, Wenhui Sun, Zhongji Pu, Hongman Hou, Yongming Bao. Transcriptome Analysis of Tomato Leaf Spot Pathogen Fusarium proliferatum: De novo Assembly, Expression Profiling, and Identification of Candidate Effectors.Int. J. Mol. Sci. 2018, 19(31),doi:10.33-39

  6. Yue Zhang, Fangling Ji, Jingyun Wang, Zhongji Pu, Bo Jiang, Yongming Bao. Purification and characterization of a novel organic solvent tolerant and cold adapted lipase fromPsychrobactersp. ZY124. Extremophiles 2018, 22: 287–300.

  7. Wenbo Hao, Fangling Ji, Jingyun Wang, Yuepeng Wang, Yue Zhang, Yongming Bao. Metabolic engineering of Bacillus sp. for diacetyl production.Process Biochemistry2017, 58: 69–77.

  8. Qin Tang, Fangling Ji, Jingyun Wang, Lianying Guo, Yachen Li, Yongming Bao.Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. European Journal of Pharmaceutical Sciences 2017, 109: 223-232.

  9. Zhongji Pu, Fangling Ji, Jingyun Wang, Yue Zhang, Wenhui Sun,Yongming Bao. Rational design of Meso-2, 3-butanediol dehydrogenase by molecular dynamics simulation and experimental evaluations. FEBS Letter 2017,591: 3402-3413.

  10. Bo. Jiang , R.F. Shen, J. Bia, X.S. Tianb, T Hinchliffeb Y. Xia. Catalpol: A Potential Therapeutic for Neurodegenerative Diseases Current Medicinal Chemistry,1278-1291



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